Patients w/ predisposing factors to ketoacidosis including low β-cell function reserve resulting from pancreatic disorders (eg, type 1 diabetes, history of pancreatitis or pancreatic surgery), insulin dose reduction, reduced caloric intake or increased insulin requirements due to infections, illness or surgery & alcohol abuse. Discontinue or temporary interruption of treatment if ketoacidosis is suspected. Not indicated for treatment of patients w/ type 1 DM. Discontinue treatment if Fournier's gangrene is suspected. Concomitant use w/ medications known to cause hypoglycemia eg, insulin & insulin secretagogues (eg, sulfonylureas). Evaluate renal function prior to initiation of therapy & periodically thereafter. Severe renal impairment (eGFR <30 mL/min/1.73 m
2) or ESRD. Avoid during pregnancy (2nd & 3rd trimester). Lactation. Childn & adolescents.
Sign Out
